Why capsule determines the efficacy

Update:12-10-2018
Summary:

Capsules are closely related to the efficacy of the dru […]

Capsules are closely related to the efficacy of the drug. "After the drug enters the blood, the blood drug concentration is required to be stable. The concentration of the drug in the blood is too high, which may cause adverse reactions; the concentration is too low, and the effect is not effective. So try to control it so that it is lower than the minimum poisoning concentration, and Above the minimum effective therapeutic concentration. empty capsule can help."

Professor Guo Shengrong said that some medicines are marked on the box as “sustained-release capsules”, which means that the capsules used can control the slow release of the medicine according to the design requirements, such as “Fenbid”, which is also called “Ibuprofen”. Sustained-release capsules; some are marked as "controlled release capsules", which can control the release of the contained drugs at a constant rate, such as anti-allergic "chlorpheniramine controlled release capsules"; in addition, there are "enteric capsules". Azithromycin enteric-coated capsules such as antibiotics. These capsules each have manufacturing requirements and processes.

In order to further explain the relationship between the capsule and the drug in the capsule, Professor Guo quoted a state regulation for the approval of new drugs: the main component of the capsule is edible gelatin, and one capsule must be approved by the new drug in China, and the gelatin used in the capsule must be written. Business; a few years later, if the pharmaceutical company wants to replace the gelatin supplier, it should file with the drug regulatory department and even apply for drug approval again.

“Replacing the manufacturer, the gelatin content may change, and the efficacy will change accordingly. Therefore, the drug needs to be re-approved and reviewed. The close relationship between the capsule and the efficacy can be seen.”Experts explained that it is precisely because of the different ingredients and properties of the drug that they are made into capsules, granules, tablets, oral liquids and the like in order to exert the best efficacy.